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Lenovo ThinkPad P16s Gen 4 - 16-Inch Copilot+ Mobile Workstation, AMD Ryzen AI 7 PRO 350, 32GB DDR5, 512GB SSD (21QR001QUS)

SKU: 21QR001QUS

Regular price $2,914.99 USD
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16-Inch Copilot+ Mobile Workstation with AMD Ryzen AI 7 PRO 350, 50 TOPS XDNA 2 NPU, 32GB DDR5 Expandable to 96GB, Tamper Detection, and Premier Support at 3.77 Pounds

The Lenovo ThinkPad P16s Gen 4 (21QR001QUS) is a 16-inch Copilot+ PC mobile workstation laptop built on AMD's Ryzen AI 7 PRO 350 processor with a 50 TOPS XDNA 2 neural processing unit, AMD Radeon 860M graphics, 32GB of DDR5-5600 memory expandable to 96GB, a 512GB M.2 SSD, and WiFi 7 (802.11be) connectivity in a 3.77-pound carbon fiber and glass fiber chassis.

The Ryzen AI 7 PRO 350 delivers 8 cores and 16 threads with boost speeds up to 5.00 GHz, paired with AMD's XDNA 2 NPU rated at 50 TOPS for Copilot+ PC certification and on-device AI processing. The PRO designation provides AMD PRO security features and manageability for IT-managed fleet deployments. The 32GB DDR5-5600 memory ships as two 16GB SoDIMMs in dual-channel configuration, with a maximum supported capacity of 96GB by replacing both modules for workstation-class multitasking demands.

The 16-inch WUXGA (1920x1200) IPS anti-glare display produces 400 nits of brightness with a 16:10 aspect ratio, delivering 27% more screen area than 14-inch models for spreadsheet-heavy and multi-window workflows. The low blue light panel reduces eye strain during extended work sessions. AMD Radeon 860M integrated graphics handle multi-display output, hardware-accelerated video encoding, and everyday business graphics workloads.

The 512GB M.2 SSD provides storage for OS, applications, and working files, with the M.2 slot supporting user-replaceable storage upgrades. WiFi 7 (802.11be) delivers next-generation wireless throughput, and Gigabit Ethernet via the built-in RJ-45 port provides wired connectivity. An IR camera enables Windows Hello facial recognition alongside the fingerprint reader for dual biometric authentication. Tamper detection provides hardware-level security alerting, and Premier Support provides direct access to advanced Lenovo technicians for priority issue resolution.

Where the ThinkPad P16s Gen 4 21QR001QUS Fits

  • Organizations deploying cost-effective mobile workstations with maximum upgrade headroom where the 512GB base storage and 32GB memory keep procurement costs down while the 96GB maximum RAM capacity and user-replaceable M.2 slot allow IT to scale hardware as workload demands grow
  • Security-conscious deployments requiring hardware tamper detection where the combination of tamper detection, AMD PRO manageability, IR camera with privacy shutter, and fingerprint reader provides layered physical and digital security for regulated industries and sensitive work environments
  • Mobile professionals who need large-screen workstation performance under 4 pounds where the 3.77-pound carbon fiber and glass fiber chassis delivers 16 inches of display area with the full ThinkPad port array, Premier Support, and Copilot+ PC AI capability

What the ThinkPad P16s Gen 4 21QR001QUS Delivers

  • AMD Ryzen AI 7 PRO 350 with 50 TOPS NPU: 8 cores, 16 threads, up to 5.00 GHz with AMD XDNA 2 neural processing delivering 50 TOPS for Copilot+ PC certification and AMD PRO security and manageability.
  • 32GB DDR5-5600, Expandable to 96GB: Ships with 2x16GB SoDIMMs in dual-channel configuration, with maximum supported capacity of 96GB for workstation-class multitasking demands.
  • 16-Inch WUXGA IPS Anti-Glare, 400 nit: 1920x1200 resolution in a 16:10 aspect ratio with 400-nit brightness, anti-glare coating, and low blue light technology for comfortable extended viewing.
  • 512GB M.2 SSD: Fast NVMe storage for OS and applications with user-replaceable M.2 slot for future capacity upgrades.
  • Thunderbolt 4 + Full Port Array: 2x Thunderbolt 4 (USB-C), 2x USB 3.2 Gen 1 Type-A, HDMI, and RJ-45 provide docking, display output, and peripheral connectivity without adapters.
  • 3.77 lb Carbon Fiber Build with Premier Support: Carbon fiber and glass fiber chassis at 3.77 pounds with tamper detection, dual biometric authentication, Copilot key, and Premier Support for direct access to advanced technicians.

Overview

Product: ThinkPad P16s Gen 4 (21QR001QUS)

Brand: Lenovo

Product Line: ThinkPad P Series

Part Number: 21QR001QUS

Release Date: May 2025

Copilot+ PC: Yes

Processor

CPU: AMD Ryzen AI 7 PRO 350

Cores/Threads: 8 Cores / 16 Threads

Base Clock: 2.00 GHz

Max Turbo Frequency: 5.00 GHz

Platform: AMD

NPU: AMD Ryzen AI (XDNA 2), 50 TOPS

Memory

Installed RAM: 32 GB DDR5-5600

Configuration: 2x 16GB SoDIMM (0 slots free)

Max Supported: 96 GB (2 slots)

Storage

SSD: 512 GB M.2 PCIe NVMe

Display

Size: 16 inches

Resolution: 1920 x 1200 (WUXGA)

Panel Type: IPS

Brightness: 400 nit

Color Gamut: 45% NTSC

Touch: No

Features: Anti-Glare, Low Blue Light

Graphics

GPU: AMD Radeon 860M (Integrated)

GPU Memory: Shared (DDR5)

Networking

WiFi: WiFi 7 (802.11be)

Bluetooth: Yes

Ethernet: Gigabit Ethernet (RJ-45)

Ports & Slots

Thunderbolt: 2x Thunderbolt 4 (USB-C)

USB-A: 2x USB 3.2 Gen 1 Type-A

Video Output: HDMI

Network: RJ-45 Ethernet

Camera & Security

Camera: 5MP with IR

Privacy: Physical Shutter

Biometrics: IR Camera + Fingerprint Reader

Security: Tamper Detection

Input

Keyboard: Backlit, English

Copilot Key: Yes

Power & Physical

AC Adapter: 65W USB-C

Weight: 3.77 lb (1.71 kg)

Dimensions: 14.2 x 9.9 x 0.93 in

Color: Black

Material: Carbon Fiber / Polycarbonate / Glass Fiber

Operating System

OS: Windows 11 Pro

Certifications

Environmental: ENERGY STAR 9.0, EPEAT Gold, TCO Certified 10.0, RoHS

Warranty

Coverage: 1 Year Manufacturer Warranty (Courier/Carry-in) + Premier Support

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